CAHn you do it?

Crinecerfont can improve CAH What is CAH and its cause? In response to stress, the body releases CRH (corticotropin-releasing hormone) from the hypothalamus, which signals the pituitary gland via CRF1 (corticotropin-releasing hormone receptor 1) to produce ACTH (adrenocorticotropic hormone). ACTH further stimulates the adrenal gland present over the kidney to synthesize cortisol, aldosterone, and androgens […]

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Let’s MASHup!!

MASH (Metabolic dysfunction associated steatohepatitis) is a severe form of non-alcoholic liver disease, previously known as NASH (Non-alcoholic steatohepatitis). It is caused by increased fat deposits and inflammation in the liver despite low alcohol consumption. This further leads to liver scarring called cirrhosis. Untreated cirrhosis causes irreversible damage to the liver leading to its failure

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A Ray of Hope – Islets transplantation for T2D patients too

Islets are a group of hormone producing cells that control blood glucose levels. Islet transplantation is considered a cure for type 1 diabetes (T1D). T1D is caused by the destruction of beta cells in islets by the body’s immune system. These beta cells produce insulin that decreases blood glucose. Islet transplantation is challenging due to

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Who pays for the research and clinical trials?

A research lab in an institute or university gets funds for research from many public and private funding agencies. The National Institute of Health (NIH) is one of the major government funding agencies. It supports 84% of biomedical research in academia, small institutes, and small businesses (source: researchamerica.org). In 2024, NIH invested $47.1 billion in

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Mito!! Give me the power to rejuvenate!

We all know that mitochondria are the powerhouse of cells because they generate energy from food. However, we did not know their involvement in cellular regeneration. Scientists at UT Southwestern Medical Center determined that liver cells with damaged mitochondria have less ability to regenerate when injured. Henceforth, allowing cells with undamaged mitochondria to grow more, rejuvenating the liver. This study was published in Science journal’s June 2024 issue.

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