Vinny Negi

Avoiding sugars in the first 1000 days of life can reduce the risk of type 2 diabetes and hypertension in your 60s – A World War II sugar rationing study

A recent study published in the Science journal showed that limiting sugar up to 1000 days from conception can reduce the risk and delay the onset of type 2 diabetes (T2D) and hypertension later in life, in their 60s. Source: Adobe Stock images Study cohort This study was based on a UK cohort of 60,183 […]

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A snapshot of worldwide diabetes prevalence over 30 years: 1990-2022

A recent study published in the Lancet determined the prevalence and treatment of diabetes among 141 million participants worldwide, from 175 countries. In 2022, the prevalence was lowest (2-5%) in western Europe and east Africa. Highest (≥ 25%) in Polynesia and Micronesia, some Caribbean, Middle East, and north Africa countries, Pakistan, and Malaysia. Although there

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A non-invasive biomarker panel for MASH

MASH (metabolic dysfunction-associated steatohepatitis) is a liver disease, where >5% fat accumulates in the liver along with inflammation and sometimes fibrosis. It is a severe form of MASLD (metabolic dysfunction associated steatotic liver disease) which is caused by just fat deposition in the liver. It is common and affects 25-30% of the global population; out

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Transparent mice are here – Not a science fiction, but a reality.

Generated by Meta AI Scientists at Stanford University have made live mice transparent, easing biomedical research and saving their lives. They used an FDA-approved food coloring dye called tartrazine, which makes the mice’s skin transparent. They used this dye on the mouse brain, abdomen, and muscle for imaging. Below is the figure of the mouse’s

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CAHn you do it?

Crinecerfont can improve CAH What is CAH and its cause? In response to stress, the body releases CRH (corticotropin-releasing hormone) from the hypothalamus, which signals the pituitary gland via CRF1 (corticotropin-releasing hormone receptor 1) to produce ACTH (adrenocorticotropic hormone). ACTH further stimulates the adrenal gland present over the kidney to synthesize cortisol, aldosterone, and androgens

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Let’s MASHup!!

MASH (Metabolic dysfunction associated steatohepatitis) is a severe form of non-alcoholic liver disease, previously known as NASH (Non-alcoholic steatohepatitis). It is caused by increased fat deposits and inflammation in the liver despite low alcohol consumption. This further leads to liver scarring called cirrhosis. Untreated cirrhosis causes irreversible damage to the liver leading to its failure

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A Ray of Hope – Islets transplantation for T2D patients too

Islets are a group of hormone producing cells that control blood glucose levels. Islet transplantation is considered a cure for type 1 diabetes (T1D). T1D is caused by the destruction of beta cells in islets by the body’s immune system. These beta cells produce insulin that decreases blood glucose. Islet transplantation is challenging due to

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Who pays for the research and clinical trials?

A research lab in an institute or university gets funds for research from many public and private funding agencies. The National Institute of Health (NIH) is one of the major government funding agencies. It supports 84% of biomedical research in academia, small institutes, and small businesses (source: researchamerica.org). In 2024, NIH invested $47.1 billion in

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